Endostatin-Expressing Stem Cells: A New Approach to Treating Endometriosis
Endometriosis is a chronic inflammatory condition characterized by abnormal blood vessel formation. Endostatin, a potent angiogenesis inhibitor, has shown potential in targeting the process of angiogenesis. In a study published in Stem Cells Translational Medicine, Peng and Zhang et al. explored the therapeutic…
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By Özge ÖzkayaStudy Sheds Light on the Molecular Mechanism of Endometriosis Lesion Formation
By Özge Özkaya
The production of a protein called Nucleotide-binding Oligomerization Domain 1 (NOD1) in ectopic mesenchymal stem cells may be associated with the formation of ectopic endometrial lesions, according to a new study published in the International Journal of Stem Cells. This…
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By Selma OransayEndometriosis Development: Pathogenesis and genomics
By Selma Oransay
In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia, hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…
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By Kasthuri NairMechanism for Migration of Endometriosis Cells in the Body
By Kasthuri Nair
Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells…
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By Yu YuHuman Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies
By Yu Yu
Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…
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